High Yield Review Articles

The articles below provide an overview and approach to many topics in oncologic critical care. We will continue to expand this collection so please check back for new resources or join our mailing list.


  • Overview of Oncologic Emergencies
  • Hyperleukocytosis and Leukostasis
  • Novel Therapies
  • Respiratory Failure in Immunocompromised Patients
  • SIADH and Hyponatremia
  • Tumor Lysis Syndrome

Overview of Oncologic Emergencies

Spring J, Munshi L. Hematology Emergencies in Critically Ill Adults: Malignant Hematology.

Chest. 2022 Feb 12:S0012-3692(22)00248-3. 

Hyperleukocytosis and Leukostasis

Shallis RM, Stahl M, Bewersdorf JP,et al. Leukocytapheresis for patients with acute myeloid leukemia presenting withhyperleukocytosis and leukostasis: a contemporary appraisal of outcomes and benefits.

Expert Rev Hematol. 2020;13(5):489-499.

Giammarco S, Chiusolo P, Piccirillo N, et al. Hyperleukocytosis and leukostasis: management of a medical emergency.

Rev Hematol. 2017;10(2):147-154.

Rollig C, Ehninger G. How I treat hyperleukocytosis in acute myeloid leukemia.

Blood. 2015;125(21):3246-3252.

Novel Therapies

Gutierrez C, Rajendram P, Pastores SM. Toxicities Associated with Immunotherapy and Approach to Cardiotoxicity with Novel Cancer Therapies.

Crit Care Clin. 2021;37(1):47 - 67.

Boll B, Subklewe M, von Bergwelt - Baildon M. Ten things the hematologist wants you to know about CAR - T cells.

Intensive Care Med. 2020;46(6):1243 - 1245.

Gutierrez C, McEvoy C, Munshi L, et al. Critical Care Management of Toxicities Associated with Targeted Agents and Immunotherapies for Cancer.

Crit Care Med. 2020;48(1):10 - 21.

Lemiale V, Meert AP, Vincent F, et al. Severe toxicity from checkpoint protein inhibitors: What intensive care physicians need to know?

Ann Intensive Care. 2019;9(1):25.

Postow MA, Sidlow R, Hellmann MD. Immune-Related Adverse Events Associated with Immune Checkpoint Blockade.

N Engl J Med. 2018;378(2):158-168.

Shimabukuro-Vornhagen A, Böll B, Schellongowski P, et al. Critical care management of chimeric antigen receptor T-cell therapy recipients. 

CA Cancer J Clin. 2022;72(1):78-93.

Respiratory Failure in Immunocompromised Patients

Azoulay E, Mokart D, Kouatchet A, et al . Acute respiratory failure in immunocompromised adults.

Lancet Respir Med. 2019;7(2):173 - 186.

Azoulay E, Russell L, Van de Louw A, et al. Diagnosis of severe respiratory infections in immunocompromised patients.

Intensive Care Med. 2020;46(2):298-314.

Ferreyro BL, Munshi L. Causes of acute respiratory failure in the immunocompromised host.

Curr Opin Crit Care. 2019;25(1):21-28.

Bondeelle L, Bergeron A. Managing pulmonary complications in allogeneic hematopoietic stem cell transplantation.

Expert Rev Respir Med. 2019;13(1):105-119.

SIADH and Hyponatremia

Yasir M, Mechanic OJ. Syndrome of Inappropriate Antidiuretic Hormone Secretion. In: StatPearls.

Treasure Island (FL) 2021.

Workeneh BT, Jhaveri KD, Rondon-Berrios H. Hyponatremia in the cancer patient.

Kidney Int. 2020;98(4):870-882.

Stem Cell Transplant

Fornwalt RA, Brigham EP, Scott Stephens R. Critical Care of Hematopoietic Stem Cell Transplant Patients.

Crit Care Clin. 2021;37(1):29-46.

Randolph BV, Ciurea SO. What the Intensivist Needs to Know About Hematopoietic Stem Cell Transplantation? In: Nates JL, Price KJ, eds.

Oncologic Critical Care. Cham: Springer International Publishing; 2020:1531-1546.

Tumor Lysis Syndrome

Adeyinka A, Bashir K. Tumor Lysis Syndrome. In:

StatPearls. Treasure Island (FL)2021.

Kala J, Finkel KW. Onconephrology.

Crit Care Clin. 2021;37(2):365-384.

Durani U, Hogan WJ. Emergencies in haematology: tumour lysis syndrome.

Br J Haematol. 2020;188(4):494-500.